In addition, among these hub genes, 10 were upregulated (CYP27A1, GATD1, HBB, JAK2, LYST, STAT2, STAT4, TRMT5, and WARS2) and 5 were downregulated (GATA2, HMGCS2, HS6ST2, SLC2A1, and SPP1) in HF (Supplementary Figure 1). This evidence concerns the gene SPP1 and hydrops fetalis.