IL1A and malignant colon neoplasm: Studies have found that CCL2, IL-1α and IL-6 secreted by TAMs can promote the proliferation of colon cancer cells (72), and the release of the matrix metalloproteinase (MMP) 1 accelerates the transition of the tumor cell cycle from the G0/G1 phase to the S phase and G2/M phase (73).CSF1 is an important cytokine involved in macrophage proliferation and differentiation, and CSF1 produced by colon cancer cells contributes to the recruitment and infiltration of TAMs.