MAPK8 and malignant colon neoplasm: Garcinia yunnanensis, a traditional Chinese medicine, has anticancer and anti-inflammatory effects, and after Garcinia yunnanensis treatment of APCmin/+ colon cancer model mice, JNK, STAT3 and ERK signaling were inhibited, M2 macrophage infiltration in the TME was reduced, and the size of tumors was reduced (219).