CSF1R and neoplasm: A synthesized compound 21 from a series of (Z)-1-(3-((1H-pyrrol-2-yl)methylene)-2-oxoindolin-6-yl)-3-(isoxazol-3-yl)urea derivatives exhibits excellent CSF-1R inhibitory activity (IC50 = 2.1nM), promoting M1 macrophage infiltration and enhancing anti-tumor immune responses (197).