In TME, several EMT-associated transcription factors (ZEB, SNAIL, and TWIST) synergize with signaling pathways in tumor cells (77–79) to induce EMT in response to stimulation by TGF-β, WNT, NOTCH, hypoxia (80–82), etc. TAMs have been demonstrated to have a key role in EMT in colon cancer. This evidence concerns the gene TGFB1 and malignant colon neoplasm.