Garcinia yunnanensis, a traditional Chinese medicine, has anticancer and anti-inflammatory effects, and after Garcinia yunnanensis treatment of APCmin/+ colon cancer model mice, JNK, STAT3 and ERK signaling were inhibited, M2 macrophage infiltration in the TME was reduced, and the size of tumors was reduced (219). Here, STAT3 is linked to colonic neoplasm.