ANGPT2 and colonic neoplasm: TAMs infiltrating the TME of colon tumors express HIF1α as an “angiogenic switch”, and respond to hypoxia signals by producing pro-angiogenic cytokines and growth factors, such as Angiopoietin-2 (Ang-2), VEGF, IL-8, CXCL1, and Fibroblast growth factor 2 (FGF-2), to induce endothelial cell recruitment, proliferation, and maturation, forming new blood vessels to promote tumor growth (67, 93, 94).