Studies have shown that safflower polysaccharide (108), Cnidium officinale polysaccharide (178) and Beta-1,6 glucan (179) can activate the NF-κB and MAPK signaling pathways in colon cancer, promote the activation of M1 macrophages in the TME to generate immune responses. This evidence concerns the gene NFKB1 and malignant colon neoplasm.