The B7 family of immune checkpoint proteins plays critical roles in tumor immune evasion, among which B7-H6 (NCR3LG1) has garnered significant attention as a tumor-selective antigen due to its minimal expression in healthy tissues and aberrant overexpression across multiple malignancies, including lung, hepatic, and pancreatic carcinomas (1–3). Here, NCR3LG1 is linked to neoplasm.