These includeFCGBP (18), GIMAP5 (19), WIPF1 (20), RASGEF1B (21), GIMAP7 (19), IGFLR1 (22), GPR35 (23), NCF1 (24), CLECL1 (25), HEXB (26) and IL10 (27) which may serve as important predictors of HNSCC in tumor microenvironment. Here, GPR35 is linked to head and neck squamous cell carcinoma.