These includeFCGBP (18), GIMAP5 (19), WIPF1 (20), RASGEF1B (21), GIMAP7 (19), IGFLR1 (22), GPR35 (23), NCF1 (24), CLECL1 (25), HEXB (26) and IL10 (27) which may serve as important predictors of HNSCC in tumor microenvironment. This evidence concerns the gene GPR35 and neoplasm.