By day 21, the OVV-01 group exhibited markedly higher levels of hCD3+ T cells, hCD3+CD8+ T cells, and hCD3+CD4+ T cells in both peripheral blood and tumor compared to the control and OVV-00 groups, indicating that OVV-01 has a stronger immunostimulatory effect than OVV-00. The gene discussed is CD8A; the disease is neoplasm.