Given that endothelial cells in the tumor microenvironment are dispensable for tumor angiogenesis (55), we generated Kctd10flox/floxCDH5CreERT2/+ mice that specifically delete Kctd10 in vascular endothelial cells (Figures 7A, B, Supplementary Figure 10G). This evidence concerns the gene KCTD10 and neoplasm.