The following 11 relevant pathways were selected: lipid and atherosclerosis pathway, AGE-RAGE signaling pathway, AMPK pathway, C-type lectin receptor pathway, insulin resistance, HIF − 1 signaling pathway, toll-like receptor signaling pathway, TNF signaling pathway, alcoholic liver disease, NAFLD, and pathways in cancer. The gene discussed is SETD2; the disease is atherosclerosis.