CXCL10 and infection: However, Alpha and BA.1 differed significantly in CXCL-10 values (median infected/asymptomatic N-seronegative with 95% CI of difference: Alpha pool-1: 1.323/0.6588 [−1.500, −0.02893]; BA.1 pool-1: 1.145/0.4689 [−1.277, −0.02541]), which may be due to the significant role of conserved sites on the S2 subunit and those around the S1/S2 cleavage site in protection against symptomatic infection [18,21].