IFNG and infection: A significant association between infection and a balance shifted towards non-conserved epitopes was revealed upon relating wild-type Spike peptide pools spanning exclusively mutated sites in SARS-CoV-2 variants to whole Spike (wild-type) peptide pools (median infected (n = 8)/asymptomatic N-seronegative (n = 6) with 95% CI of difference: Alpha mutation sites (CXCL-10//IFN-γ): 0.6035/0.1911 [−0.7671, −0.1917]//0.7165/0.3021 [−1.163, −0.05047]; BA.1 mutation sites (CXCL-10//IFN-γ): 1.559/0.4068 [−1.531, −0.5060]//1.142/0.3605 [−1.463, −0.2888]; Figure 5a–c).