This analysis showed that the Allele-1 group showed a significant effect of antibody response to COVID-19 vaccination both before and after vaccination in BMI values and, at the post-vaccination time point, in systemic levels of IL-17 and IFN-γ, and also in the ratios of IL-17/IL-10 and IFN-γ/IL-10. The gene discussed is IFNG; the disease is COVID-19.