Our scRNA-seq data further demonstrated that while cART successfully suppressed HIV-1 replication and reduced infection-induced transcriptional changes (Supplemental Tables S2 and S3), the pharmacological blockade of IFNAR signaling during cART administration additionally reversed HIV-associated transcriptional profiles in innate immune populations, particularly NK cells and innate lymphoid cells (ILCs) (Figure 2H, Supplemental Tables S2 and S3). This evidence concerns the gene IFNAR1 and infection.