In addition to survival-related genes, IFNAR blockade also significantly downregulates IL-1β production- and inflammasome-activation-related genes (module C4) (Figure 5D and Supplemental Table S5), which is reported to be a major cause of CD4+ T cell loss during HIV-1 infection [36], suggesting that IFNAR blockade may rescue ILC3s via inhibiting pyroptosis in addition to apoptosis. The gene discussed is CD4; the disease is HIV-1 infection.