RIGI and bronchiolitis: A study by Lee et al. highlighted how viral antigen recognition activates a signaling pathway involving nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) and retinoic acid-inducible gene I (RIG-1), leading to increased TSLP production and a robust Th2 immune response, contributing to the pathology of severe bronchiolitis in some cases, potentially progressing to asthma [74].