A recent study investigating the sensitizing effect of CCNU alone, temozolamide alone, and their combination with irradiation (4 Gy) in J3TBG [27] cells revealed that combining CCNU and temozolamide with radiation significantly reduced J3TBG glioma cell survival, even after long-term drug exposure that leads to the generation of either CCNU- or temozolamide-resistant cells. The gene discussed is CCNO; the disease is central nervous system cancer.