Notably, it is reported that PD-L1-positive TILs are associated with increased levels of activated TILs [28], reflecting an active anti-tumor immunity that, despite being balanced by the PD-1/PD-L1/PD-L2 pathway, is sufficient to generate an inflamed and immunosuppressive tumor microenvironment, capable of damaging tissues, thus leading to ulcer formation and contributing to tumor progression. This evidence concerns the gene CD274 and neoplasm.