EGFR and colorectal cancer: Additionally, there exist VDRE in the promoters of EGFR, and VDR could bind to the EGFR VDRE sequence in the absence of ligands, indicating that VDR may regulate the transcription of EGFR [19,21], and EGFR-VDR crosstalk has been observed in colorectal cancer [22], suggesting a functional relationship between VDR and EGFR.