In this study, we explored the role of VDR and 1,25(OH)2D3 in modulating the interplay between EGFR and FASN, as well as the role and mechanisms by which VDR contributes to 1,25(OH)2D3-mediated inhibition of gefitinib resistance in NSCLC. Here, VDR is linked to non-small cell lung carcinoma.