Based on this, this study intends to use interdisciplinary strategies to (1) construct a machine learning model to predict the anti-tumor activity of cinnamic acid, (2) use bioinformatics technology to screen its potential targets, (3) use molecular docking and dynamics simulation and analysis of the details of ligand-target interactions, and, in combination with in vitro experiments, (4) use cinnamic acid to induce apoptosis on Hep3B hepatocarcinoma cells and determine the regulatory effect of the PI3K/AKT pathway. This evidence concerns the gene AKT1 and neoplasm.