Through topological analysis (betweenness ≥ 257.821, closeness ≥ 0.00237, degree ≥ 17.195), 39 core targets were screened (Figure 3B), including PIK3R1, AKT1, MAPK1, etc., which may play a central role in the treatment of liver cancer. This evidence concerns the gene AKT1 and liver cancer.