Nevertheless, in EAC samples, upregulated CALML4 was predominantly shown in Rap1, Ras signaling pathway, kaposi sarcoma-associated herpesvirus infection, and phosphatidylinositol signaling system, which was closely related to tumor cell invasion, cancer cell proliferation, and uncontrolled cell metastasis [17,18,19]. This evidence concerns the gene CALML4 and neoplasm.