Importantly, they have demonstrated the capacity to infiltrate solid tumors and modulate the immunosuppressive tumor microenvironments, and because of their MHC-independent antigen recognition and low alloreactivity, they are associated with reduced risk of graft-versus-host disease (GvHD), making them especially attractive for allogeneic cell therapies and engineering platforms such as CAR constructs [14,15,16,17,18]. Here, HLA-C is linked to neoplasm.