PIK3CA and rheumatoid arthritis: Additionally, naringin and diosmetin suppress inflammatory and invasive RA-FLS activity via inhibition of the PI3K/Akt and MAPK/ERK pathways, reducing cytokine and matrix metalloproteinase production and enhancing apoptosis [35,45], while genistein further modulates ROS/Akt/NF-κB signaling [36].