Thus, restoration of PTEN expression via 5-azadC or genetic overexpression (Ad-PTEN) resulted in a 45–60% reduction in p-AKT levels, suppression of proinflammatory cytokine and metalloproteinase expression, as well as a significant decrease in edema in inflammation models [30]; combined modulation of Wnt5a signaling with inhibition of PI3K, MAPK, and ROCK led to marked reductions in RA-FLS migration and production of inflammatory mediators [31]. This evidence concerns the gene PTEN and rheumatoid arthritis.