Equally noteworthy is that ex vivo analysis of synovial biopsies following temsirolimus therapy demonstrated an increase in the apoptotic activity of RA-FLSs from +1.5 to +3.0 SD according to Annexin V/PI [83], a finding that closely mirrors our meta-analytical results (g = +2.65) and corresponds to the spectrum of changes identified in our qualitative assessment, while the degree of IL-6 suppression entirely conforms to the confidence interval derived from the meta-analytic data (Hedges’ g from –0.9 to –7.6). This evidence concerns the gene ANXA5 and rheumatoid arthritis.