Fourteen clusters exhibited a pronounced negative integral effect (|g| ≥ 0.8 SD), indicative of a substantial diminution in proliferation, proinflammatory cytokine secretion, and cellular migration/invasion; the most prominent alterations were documented for TNF-α-induced proliferation of RA-FLSs (g ≈ –5.1 SD), IL-6 expression by qPCR upon Semaphorin 5A stimulation (g ≈ –11.1 SD), and IL-8 secretion by ELISA in MH7A (+TNF-α) (g ≈ –6.5 SD). The gene discussed is IL6; the disease is rheumatoid arthritis.