Analogous reductions in local IL-6 concentrations within synovial fluid and marked diminutions in pannus volume (up to 70%) faithfully recapitulate the patterns of regression in the inflammatory-proliferative phenotype of RA-FLSs elucidated in our work, thus highlighting a profound congruence between cellular and tissue-level alterations [73,82]. The gene discussed is IL6; the disease is rheumatoid arthritis.