To achieve these objectives, the study was structured around the following aims: (i) to conduct a systematic search and critical appraisal of in vitro studies focused on PI3K/AKT/mTOR inhibition in RA-FLSs; (ii) to perform a meta-analytical quantification of the effects of these inhibitors on functional and molecular outcomes; and (iii) to investigate the impact of experimental variables on both the magnitude and reproducibility of the observed effects. Here, PIK3CA is linked to rheumatoid arthritis.