PIK3CA and rheumatoid arthritis: The conducted meta-analysis demonstrates that inhibition of the PI3K/AKT/mTOR signaling cascade is associated with a marked suppression of the proliferative activity of RA-FLSs, and these effects are consistently reproducible regardless of the stimulus employed—be it Semaphorin-5A or TNF-α (g ranging from –2.80 to –5.13; see Figure 3H).