Meanwhile, according to the current approach to AD pathogenesis, its integral, mutually reinforcing components include the excessive accumulation of amyloid-beta (Aβ) [2] and abnormal tau protein phosphorylation, as well as the formation of neurofibrillary tangles (NFTs) [7], neuroinflammation [8,9], mitochondrial dysfunction, and oxidative stress [10,11] (Figure 1). The gene discussed is MAPT; the disease is Alzheimer disease.