IL13 and acute respiratory distress syndrome: Moreover, IL-13 has a dual nature; it is implicated in tissue repair processes following lung injury (it aids in matrix remodeling and the induction of epithelial-derived type 2 effector molecules, which are crucial for effective repair and recovery from lung damage) [64], and it has been shown to impair the integrity of the bronchial epithelial barrier by disrupting tight junctions, which can exacerbate asthma symptoms and potentially contribute to ALI.