PPARG and arthritic joint disease: BCP has been shown to act as a CB2 receptor agonist that indirectly up-regulates Peroxisome Proliferator-Activated Receptor Gamma (PPAR-γ) and its co-activator Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha (PGC-1α) in inflamed tissues, a mechanism supported by studies in arthritis and vascular inflammation models [45].