In several current review articles, the authors present comprehensive results on the prevention and treatment of oral cancer using plant extracts, such as Pinus densiflora and Trifolium pratens, which act by inhibition of oncogenic transcription (e.g., STAT3), activation of MAPK/ERK, PARP, PUMA, and p53 pathways [176,181,231]. Here, TP53 is linked to lip and oral cavity carcinoma.