In recent years, our research group obtained the active component rich in caffeoylquinic acid compounds (CQAs) from SP and confirmed that it possesses hepatoprotective effects on cholestatic mice by regulating enterohepatic circulation of bile [22], and could improve lipid accumulation in NAFLD mice by regulating the AMPK/FXR signaling pathway [23]. This evidence concerns the gene NR1H4 and metabolic dysfunction-associated steatotic liver disease.