The intratumoral peritumoral injections of 20 μg Ag-citrate-5 nm combined with 150 μg anti-PD-1 (three doses, 4-day intervals) led to a 70% reduction in tumor bioluminescence and a 2- to 3-fold increase in CD8+ T-cell infiltration compared to either monotherapy [97]. Here, PDCD1 is linked to neoplasm.