CD274 and neoplasm: One of the most prevalent topics discussed is the concept of “hot” versus “cold” tumors, referring to high and low infiltration of immune cells within the TME [113] “Cold”, or non-inflamed tumors, typically show minimal response to therapy, while “hot” or inflamed tumors, show better response due to a higher tumor mutational burden (TMB), increased neoantigens, and increased expression of PD-L1 [113].