CD274 and neoplasm: Additionally, the programmed cell death ligand 1/NOD-, LRR-, and pyrin domain containing protein 3 (PD-L1/NLRP3) inflammasome pathway recruits polymorphonuclear myeloid-derived suppressor cells (PMN-MDSCs) that mediate apoptosis in TILs (tumor-infiltrating lymphocytes), further preventing T cell activity [58].