In HIV-TB co-infected and HIV mono-infected individuals, the expression levels of TIM-3 showed a significant positive Spearman’s r correlation with CTLA-4 (r = 0.54, p = 0.0057), LAG-3 (r = 0.54, p = 0.0077) and PD-1 (r = 0.68, p = 0.0006) (Figure 3B–D, respectively), but not significant with TIGIT (Figure 3A, respectively). The gene discussed is LAG3; the disease is tuberculosis.