A cross-sectional assessment of absolute CD4+ T-cell count and plasma viral load, in our recruited study subjects, revealed a lower mean absolute CD4+ T-cell count and significantly higher mean plasma viral load in HIV-TB co-infected individuals in comparison to HIV mono-infected individuals, confirming the disease severity and propensity of a faster HIV disease progression in co-infected individuals when compared to HIV-only infected ones, in these study groups. Here, CD4 is linked to tuberculosis.