The gene expression of ICMs, TIM-3, LAG-3, PD-1 and CTLA-4 in terms of mRNA abundance was found to be significantly upregulated in PBMCs of HIV-TB co-infected individuals as compared to HIV mono-infected and TB mono-infected individuals in our study subjects, indicating a dysregulated expression of ICMs in co-infected host. The gene discussed is CTLA4; the disease is tuberculosis.