The frequencies of TIM-3+ CD4+ (r = −0.57, p = 0.0037), TIM-3+ CD8+ T cells (r = −0.69, p = 0.0003), TIGIT+ CD4+T cells (r = −0.47, p = 0.0238), TIGIT+ CD8+T cells (r = −0.41, p = 0.0441), CTLA-4+ CD4+ T cells (r = −0.69, p = 0.0005), CTLA-4+ CD8+ T cells (r = −0.65, p = 0.0015), LAG-3+ CD4+ T cells (r = −0.63, p = 0.0017), and PD-1+ CD4+ T cells (r = −0.73, p = 0.0001) and PD-1+ CD8+ T cells (r = −0.66, p = 0.0006) in HIV mono-infected and HIV-TB co-infected individuals were negatively correlated with their peripheral blood absolute CD4+ T cell count (Figure 6A–G,I,J, respectively). This evidence concerns the gene TIGIT and tuberculosis.