An examination of the prevalence of SARS-CoV-2 spike gene mutations across ABO blood groups in COVID-19 patients was conducted, focusing on mutations including N501Y, D614G, K417N, N440K, E484K, P681R, T547K, R346T–R346Y, H69del, and V70del (Table 4). The gene discussed is ABO; the disease is COVID-19.