Hereditary hemochromatosis is caused by mutations in iron regulatory genes, including HAMP (hepcidin gene), HFE (hemochromatosis gene), TFRC (transferrin receptor), HJV (hemojuvelin), and SLC40A1 (ferroportin), and heterozygous mutations in BMP6 pro-peptide [38,39,40,41]. The gene discussed is TFRC; the disease is hemochromatosis type 1.