NR4A1 and Hepatic fibrosis: For example, numerous studies show that quercetin inhibits induced hepatic fibrosis and hepatic stellate cell activation [158,159,160,161,162] by modulating many of the same responses observed for NR4A1 ligands, and the effects of quercetin on kidney fibrosis [163,164,165] were also similar to those observed for NR4A1/ligands (Table 1).