NR4A1 and cardiac hypertrophy: In addition, NR4A1 regulates mTOR signaling in angiotensinαII-induced cardiac hypertrophy [37]; NR4A1 also enhances muscle mass in mice through IGF1-induced activation of mTOR [38], and in a mouse model of Parkinson’s disease the anti-inflammatory effect of NR4A1 is also associated with NRF2 [39].