There is also evidence that NR4A1 “may be a sensor of oxidative stress and an inhibitor of vascular remodeling” [109], and a recent study showed that metformin inhibited myocardial ischemia–reperfusion injury and this is due, in part, to enhanced NR4A1 production and receptor-dependent induction of isocitrate dehydrogenase1 [110]. The gene discussed is NR4A1; the disease is myocardial ischemia.