NFE2L2 and Hyperglycemia: It is a multifaceted agent: an antioxidant and anti-inflammatory molecule that preserves NO and endothelial function; an inhibitor of pathological signaling (NF-κβ, AT1R, PKC, MAPKs) that drives vascular and cardiac remodeling; an activator of cell-survival pathways (PI3K/Akt, Nrf2) that prevent cell death; and a modulator of metabolism that reduces risk factors like dyslipidemia and hyperglycemia.