INSR and obesity due to melanocortin 4 receptor deficiency: An additional pair of SNPs present in the intronic region of phosphotyrosine interaction domain containing 1 (PID1) emerged in our analysis that have also been reported to regulate key metabolic processes, including the clearance of triglyceride-rich lipoproteins as well as antagonizing insulin receptor signaling, and common variants in PID1 are associated with obesity and cardiometabolic disease.