Western blotting showed strong upregulation of apoptosis-related proteins (cleaved PARP, cleaved caspase-3, cleaved caspase-8) in FGFR2-high NCI-H716 cells, but not in FGFR-low CRC lines such as HCT116, DLD-1, and HT29 (Supplementary Figure S2A). This evidence concerns the gene CASP8 and colorectal carcinoma.