Subsequently, we systematically investigated the synergistic mechanism of EGCG and taurine in regulating lipid metabolism disorders in rats through comprehensive analysis of body weight, serum lipid levels, lipid metabolism-related enzyme activities, liver function, antioxidant enzyme activities, gut microbiota, short-chain fatty acids, metabolomics, and the PPARα/FAS signaling pathway, providing scientific evidence for evaluating polyphenol–taurine complexes in improving lipid metabolism disorders. This evidence concerns the gene PPARA and Disorder of lipid metabolism.