Qiu et al. demonstrated that hyperammonemia triggers the activation of IkappaB (IκB) kinase, promotes nuclear translocation of nuclear factor kappa B (NF-κB), facilitates the binding of the NF-κB p65 subunit to specific regions of the myostatin promoter, and ultimately induces transcription of the myostatin gene [14]. The gene discussed is NFKB1; the disease is Hyperammonemia.