AKT1 and Alzheimer disease: Parallel findings in animal models, including DNCB-induced AD in BALB/c mice, showed that calcifediol inhibited activation of inflammatory signaling pathways (STAT3/AKT/mTOR), reduced the expression of AQP3—a protein associated with transepidermal water loss—and upregulated the expression of VDR and VDBP [98,134].