The importance of IL-17 in these processes is confirmed by studies in IL-17 knockout mice, in which the oxazolone-induced AD model showed significantly reduced ear swelling, decreased inflammatory infiltration in the skin, and lower levels of Th2 cytokines, as well as improvements in barrier function parameters, such as transepidermal water loss and lipid distribution in the stratum corneum [85]. The gene discussed is IL17A; the disease is Alzheimer disease.