Although there is not a bona fide asprosin receptor, PTPRD has been identified as a potential orexigenic receptor for asprosin in hypothalamic AgRP neurons, since genetic ablation of PTPRD leads to loss of appetite, resistance to diet-induced obesity, and lack of response to asprosin [11]. This evidence concerns the gene FBN1 and obesity due to melanocortin 4 receptor deficiency.