The physiopathological components to explain the origin of PCOS include (1) a metabolic disorder resulting from insulin resistance, (2) disruptions in follicular development and steroidogenesis, (3) hyperactivity of the sympathetic innervation of the ovaries, and (4) neuroendocrine dysfunction produced by an increase in the secretion of the gonadotropin-releasing hormone (GnRH) and the luteinizing hormone (LH) [10]. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.