Analysis was conducted on 3051 metabolic compounds—518 primary metabolites (154 known), 1689 lipids (582 known) and 844 biogenic amines (146 known)—which were subsequently analyzed and statistically correlated to age, BMI, smoking, race, ethnicity, tumor stage, Gleason score, PSA at diagnosis, post-RP PSA and PSA recurrence. The gene discussed is KLK3; the disease is neoplasm.