For instance, in a murine model of MASH induced by a high-fat diet, the administration of ginger essential oil was found to inhibit MASH progression by suppressing the NLRP3 inflammasome and modulating the gut microbiota-LPS-TLR4 pathway, which led to a reduction in plasma ALT levels and hepatic pro-inflammatory cytokine levels [9]. Here, TLR4 is linked to metabolic dysfunction-associated steatohepatitis.