Previous studies conducted in healthy dogs, dogs with food responsive enteropathy, and dogs with mild inflammatory bowel disease have demonstrated that supplementation with a range of prebiotics, including mannooligosaccharides (MOSs), galactooligosaccharide (GOSs), β-glucans, and prebiotic blends (FOS + MOS + GOS + β-glucan; β-glucan + MOS), did not result in significant differences in fecal SCFA production (acetate, propionate, butyrate) in dogs who received prebiotics compared with placebo [49,50]. The gene discussed is PPIB; the disease is Abnormal intestine morphology.