SH2D3C and Sepsis: This isolate, which was collected from a 72-year-old man who passed away from sepsis while hospitalized for COVID-19 pneumonia, also featured two distinguishing nsp3 mutations, as discussed previously: the globally rare nsp3_618/D:126 mutation and the absence of the B.1.1.7 (Alpha) lineage-defining mutation nsp3_1412/T.