Moreover, AuNPs were found to inhibit retinal neovascularization through the suppression of VEGFR-2 activation in a retinopathy of prematurity (ROP) animal model, which not only hindered angiogenesis but also prevented the auto-phosphorylation of VEGFR-2, thus mitigating the initiation of the ERK 1/2 pathway [64]. The gene discussed is KDR; the disease is retinopathy of prematurity.