The particle size analysis of lycopene-loaded SLNs revealed an average size of 151.1 ± 2.3 nm. Electron microscopy examination confirmed that the nanoparticles were spherical, with an encapsulation efficiency of 85.76 ± 2.75%. Assessment of the anti-tyrosinase effects of SLNs demonstrated a significant reduction in cellular tyrosinase activity, melanin synthesis, and reactive oxygen species levels. Notably, SLNs effectively inhibited melanin production while exhibiting minimal toxicity toward melanoma cells. Here, TYR is linked to melanoma.