A single dose of 10 mg/kg CUSP06 significantly inhibited tumor growth in a CDH6-low cholangiocarcinoma PDX model (LD-2214, CDH6 H-score = 60) compared to the vehicle or IgG-T1000-e control groups (p < 0.005) (Figure 4D). This evidence concerns the gene CDH6 and cholangiocarcinoma.