CDH6 and hereditary clear cell renal cell carcinoma: In healthy adults, CDH6 is expressed at low levels in kidney, mammary gland, and thymus, while higher expression is seen in a majority of patients with recurrent ovarian cancer [7,8,9] and renal cell carcinoma [10], as well as, less frequently, across other solid tumors including cholangiocarcinoma, uterine serous carcinoma, glioma, lung, pancreatic and thyroid cancers [11,12,13].