GBA1 and Parkinson disease: The combination of Streptococcus pyogenes Cas9-High Fidelity 1 (SpCas9-HF1) with adenine base editor 8e (ABE8e) delivered through split-intein dual-AAV configurations enables the correction of PD-related GBA1 variant mutations in patient-derived neurons by restoring lysosomal β-glucocerebrosidase activity [84].