ALS causes the death of upper and lower motor neurons through several converging mechanisms including excitotoxic glutamate, RNA foci (due to chromosome 9 open reading frame 72 (C9orf72)), misfolded superoxide dismutase 1 (SOD1), and TAR DNA-binding protein 43 (TDP-43) pathology [23]. Here, TARDBP is linked to amyotrophic lateral sclerosis.