Similarly, gold-nanoparticle-delivered GPX4-targeting PROTAC (Au-PGPD) effectively induced selective GPX4 degradation in acute lymphoblastic leukemia (ALL) cells while sparing normal cells, demonstrating potent antitumor activity with minimal off-target effects—highlighting the potential of noble metal platforms for precision protein degradation therapeutics [86]. Here, GPX4 is linked to acute lymphoblastic leukemia.