Additional studies have shown that melittin downregulates oncogenic pathways, including Akt, NF-κB, hypoxia-inducible factor 1-alpha (HIF-1α), Wnt, and signal transducer and activator of transcription 3 (STAT3), further supporting its ability to interfere with cancer-associated signaling networks [20,21]. The gene discussed is STAT3; the disease is cancer.