Mechanistic studies in HCC cell lines suggest that melittin acts through multiple pathways, including the inhibition of cell cycle progression—specifically G0/G1 arrest via modulation of the methyl-CpG-binding protein 2/Sonic hedgehog signaling axis—disruption of survival signaling, such as the histone deacetylase 2/phosphatase and tensin homolog/Akt pathway, and the induction of apoptosis [10]. Here, AKT1 is linked to hepatocellular carcinoma.