For example, Peng et al. showed that 5-FU nanoparticles regulate the Wnt/β-catenin signaling pathway and thereby inhibit the proliferation of SCC cells and induce apoptosis [196]; Tian et al. found that 5-FU triggers anti-tumor immunity by activating the Stimulator of Interferon Genes (STING) pathway in cancer cells and enhancing the immune response against melanoma cancer cells [197]. The gene discussed is STING1; the disease is neoplasm.