Inhalable liposomal spray-dried powder for lung cancer; sustained release (65% over 96 h), enhanced cytotoxicity against MCF-7 and A549 cells (IC50: 24.4 nM & 55.3 nM), improved lung targeting, lower hepatic metabolism (due to CYP3A4 deficiency), higher AUC and Cmax, prolonged t1/2, and reduced clearance in rat model. The gene discussed is CYP3A4; the disease is lung cancer.