This process is mediated by signaling molecules such as fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), and platelet-derived growth factor (PDGF), all of which are present in the early TME and are essential for establishing blood and lymphatic conduits that support tumor nutrition and metastatic dissemination [20,21]. The gene discussed is VEGFA; the disease is neoplasm.